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Oct 28

Distributed fixed-point algorithms for dynamic convex optimization over decentralized and unbalanced wireless networks

We consider problems where agents in a network seek a common quantity, measured independently and periodically by each agent through a local time-varying process. Numerous solvers addressing such problems have been developed in the past, featuring various adaptations of the local processing and the consensus step. However, existing solvers still lack support for advanced techniques, such as superiorization and over-the-air function computation (OTA-C). To address this limitation, we introduce a comprehensive framework for the analysis of distributed algorithms by characterizing them using the quasi-Fejér type algorithms and an extensive communication model. Under weak assumptions, we prove almost sure convergence of the algorithm to a common estimate for all agents. Moreover, we develop a specific class of algorithms within this framework to tackle distributed optimization problems with time-varying objectives, and, assuming that a time-invariant solution exists, prove its convergence to a solution. We also present a novel OTA-C protocol for consensus step in large decentralized networks, reducing communication overhead and enhancing network autonomy as compared to the existing protocols. The effectiveness of the algorithm, featuring superiorization and OTA-C, is demonstrated in a real-world application of distributed supervised learning over time-varying wireless networks, highlighting its low-latency and energy-efficiency compared to standard approaches.

  • 3 authors
·
Mar 3, 2024

Convergence of Iterative Water-Filling in Multi-User Non-Cooperative Power Control: A Comprehensive Analysis for Sequential, Simultaneous, and Asynchronous Schemes

Non-cooperative game theory provides a robust framework for analyzing distributed resource allocation in multi-user wireless networks, with Iterative Water-Filling (IWF) emerging as a canonical solution for power control problems. Although classical fixed-point theorems guarantee the existence of a Nash Equilibrium (NE) under mild concavity and compactness conditions, the convergence of practical iterative algorithms to that equilibrium remains a challenging endeavor. This challenge intensifies under varying update schedules, interference regimes, and imperfections such as channel estimation errors or feedback delay. In this paper, we present an in-depth examination of IWF in multi-user systems under three different update schemes: (1) synchronous sequential updates, (2) synchronous simultaneous updates, and (3) totally asynchronous updates. We first formulate the water-filling operator in a multi-carrier environment, then recast the iterative process as a fixed-point problem. Using contraction mapping principles, we demonstrate sufficient conditions under which IWF converges to a unique NE and highlight how spectral radius constraints, diagonal dominance, and careful step-size selection are pivotal for guaranteeing convergence. We further discuss robustness to measurement noise, partial updates, and network scaling to emphasize the practical viability of these schemes. This comprehensive analysis unifies diverse threads in the literature while offering novel insights into asynchronous implementations. Our findings enable network designers to ascertain system parameters that foster both stable convergence and efficient spectrum usage.

  • 1 authors
·
Feb 17, 2025

Are Your Reasoning Models Reasoning or Guessing? A Mechanistic Analysis of Hierarchical Reasoning Models

Hierarchical reasoning model (HRM) achieves extraordinary performance on various reasoning tasks, significantly outperforming large language model-based reasoners. To understand the strengths and potential failure modes of HRM, we conduct a mechanistic study on its reasoning patterns and find three surprising facts: (a) Failure of extremely simple puzzles, e.g., HRM can fail on a puzzle with only one unknown cell. We attribute this failure to the violation of the fixed point property, a fundamental assumption of HRM. (b) "Grokking" dynamics in reasoning steps, i.e., the answer is not improved uniformly, but instead there is a critical reasoning step that suddenly makes the answer correct; (c) Existence of multiple fixed points. HRM "guesses" the first fixed point, which could be incorrect, and gets trapped there for a while or forever. All facts imply that HRM appears to be "guessing" instead of "reasoning". Leveraging this "guessing" picture, we propose three strategies to scale HRM's guesses: data augmentation (scaling the quality of guesses), input perturbation (scaling the number of guesses by leveraging inference randomness), and model bootstrapping (scaling the number of guesses by leveraging training randomness). On the practical side, by combining all methods, we develop Augmented HRM, boosting accuracy on Sudoku-Extreme from 54.5% to 96.9%. On the scientific side, our analysis provides new insights into how reasoning models "reason".

  • 2 authors
·
Jan 15

Aligning One-Step Generative Models with Reward-Weighted Transport Distillation

One-step generators enable high-quality visual generation with a single network evaluation, but their post-training is difficult: general implicit generators provide neither tractable likelihoods nor denoising trajectories, and many rewards are non-differentiable. We introduce Reward-Weighted Transport Distillation (RWTD), a post-training method that requires only generated samples and scalar reward evaluations. Rather than aligning solely to the conventional reward-tilted reference distribution, RWTD constructs an adaptive target that mixes separately tilted current and reference distributions. The current component incorporates improvements discovered during training, while the reference component anchors the target to the pretrained generator. RWTD realizes this target through feature-space optimal transport and fixed-point regression. Theoretical analysis shows that the fixed-point distributions of RWTD interpolate between off-policy reward tilting of the reference and on-policy tilting of the current model, providing a principled approach to balancing reward adaptation with retention of prior knowledge. Empirically, RWTD substantially improves the GenEval score of the one-step SANA Sprint 1.6B backbone from 0.73 to 0.80, while separate preference alignment experiments demonstrate strong cross-reward generalization that yields balanced improvements and preservation of compositional capabilities.

JPmHC Dynamical Isometry via Orthogonal Hyper-Connections

Recent advances in deep learning, exemplified by Hyper-Connections (HC), have expanded the residual connection paradigm by introducing wider residual streams and diverse connectivity patterns. While these innovations yield significant performance gains, they compromise the identity mapping property of residual connections, leading to training instability, limited scalability, and increased memory overhead. To address these challenges, we propose JPmHC (Jacobian-spectrum Preserving manifold-constrained Hyper-Connections), a framework that replaces identity skips with a trainable linear mixer acting on n parallel streams while explicitly controlling gradient conditioning. By constraining the mixer M on operator-norm-bounded manifolds (e.g., bistochastic, Stiefel, Grassmann), JPmHC prevents gradient pathologies and enhances stability. JPmHC introduces three key contributions: (i) a free-probability analysis that predicts Jacobian spectra for structured skips, providing actionable design rules for mixer selection; (ii) memory-efficient implicit differentiation for fixed-point projections, reducing activation memory and synchronization overhead; and (iii) a Stiefel-constrained mixer via Cayley transforms, ensuring orthogonality without post-hoc normalization. Empirical evaluations on ARC-AGI demonstrate that JPmHC achieves faster convergence, higher accuracy, and lower computational cost compared to bistochastic baselines, with a rank-p Grassmannian variant tracking between the two -- consistent with the spectral theory predictions. As a flexible and scalable extension of HC, JPmHC advances spectrum-aware, stable, and efficient deep learning, offering insights into topological architecture design and foundational model evolution. \newline \newline

  • 3 authors
·
Feb 20

Linearized Optimal Transport for Analysis of High-Dimensional Point-Cloud and Single-Cell Data

Single-cell technologies generate high-dimensional point clouds of cells, enabling detailed characterization of complex patient states and treatment responses. Yet each patient is represented by an irregular point cloud rather than a simple vector, making it difficult to directly quantify and compare biological differences between individuals. Nonlinear methods such as kernels and neural networks achieve predictive accuracy but act as black boxes, offering little biological interpretability. To address these limitations, we adapt the Linear Optimal Transport (LOT) framework to this setting, embedding irregular point clouds into a fixed-dimensional Euclidean space while preserving distributional structure. This embedding provides a principled linear representation that preserves optimal transport geometry while enabling downstream analysis. It also forms a registration between any two patients, enabling direct comparison of their cellular distributions. Within this space, LOT enables: (i) accurate and interpretable classification of COVID-19 patient states, where classifier weights map back to specific markers and spatial regions driving predictions; and (ii) synthetic data generation for patient-derived organoids, exploiting the linearity of the LOT embedding. LOT barycenters yield averaged cellular profiles representing combined conditions or samples, supporting drug interaction testing. Together, these results establish LOT as a unified framework that bridges predictive performance, interpretability, and generative modeling. By transforming heterogeneous point clouds into structured embeddings directly traceable to the original data, LOT opens new opportunities for understanding immune variation and treatment effects in high-dimensional biological systems.

  • 5 authors
·
Oct 24, 2025

4D Vessel Reconstruction for Benchtop Thrombectomy Analysis

Introduction: Mechanical thrombectomy can cause vessel deformation and procedure-related injury. Benchtop models are widely used for device testing, but time-resolved, full-field 3D vessel-motion measurements remain limited. Methods: We developed a nine-camera, low-cost multi-view workflow for benchtop thrombectomy in silicone middle cerebral artery phantoms (2160p, 20 fps). Multi-view videos were calibrated, segmented, and reconstructed with 4D Gaussian Splatting. Reconstructed point clouds were converted to fixed-connectivity edge graphs for region-of-interest (ROI) displacement tracking and a relative surface-based stress proxy. Stress-proxy values were derived from edge stretch using a Neo-Hookean mapping and reported as comparative surface metrics. A synthetic Blender pipeline with known deformation provided geometric and temporal validation. Results: In synthetic bulk translation, the stress proxy remained near zero for most edges (median approx 0 MPa; 90th percentile 0.028 MPa), with sparse outliers. In synthetic pulling (1-5 mm), reconstruction showed close geometric and temporal agreement with ground truth, with symmetric Chamfer distance of 1.714-1.815 mm and precision of 0.964-0.972 at τ= 1 mm. In preliminary benchtop comparative trials (one trial per condition), cervical aspiration catheter placement showed higher max-median ROI displacement and stress-proxy values than internal carotid artery terminus placement. Conclusion: The proposed protocol provides standardized, time-resolved surface kinematics and comparative relative displacement and stress proxy measurements for thrombectomy benchtop studies. The framework supports condition-to-condition comparisons and methods validation, while remaining distinct from absolute wall-stress estimation. Implementation code and example data are available at https://ethanuser.github.io/vessel4D

  • 5 authors
·
Apr 7

Convergent Graph Solvers

We propose the convergent graph solver (CGS), a deep learning method that learns iterative mappings to predict the properties of a graph system at its stationary state (fixed point) with guaranteed convergence. CGS systematically computes the fixed points of a target graph system and decodes them to estimate the stationary properties of the system without the prior knowledge of existing solvers or intermediate solutions. The forward propagation of CGS proceeds in three steps: (1) constructing the input dependent linear contracting iterative maps, (2) computing the fixed-points of the linear maps, and (3) decoding the fixed-points to estimate the properties. The contractivity of the constructed linear maps guarantees the existence and uniqueness of the fixed points following the Banach fixed point theorem. To train CGS efficiently, we also derive a tractable analytical expression for its gradient by leveraging the implicit function theorem. We evaluate the performance of CGS by applying it to various network-analytic and graph benchmark problems. The results indicate that CGS has competitive capabilities for predicting the stationary properties of graph systems, irrespective of whether the target systems are linear or non-linear. CGS also shows high performance for graph classification problems where the existence or the meaning of a fixed point is hard to be clearly defined, which highlights the potential of CGS as a general graph neural network architecture.

  • 3 authors
·
Jun 3, 2021

Polynomial Acceleration of Alternating Projections: Chebyshev Acceleration, Convergence Rates, and Retractions

Alternating projections (AP) near a clean intersection of smooth manifolds can converge slowly when the Friedrichs angle is small. We develop the Fixed-Point Manifold Acceleration (FPMA) framework for {local convergence and polynomial acceleration of} smooth maps that fix a manifold pointwise. {Under suitable regularity and uniform normal spectral stability, FPMA establishes local R-linear convergence and a smooth limiting map inducing a local retraction. At fixed points, consistent polynomial acceleration with p(1)=1 preserves the selected limit's first-order response to normal initial perturbations whenever the transformed normal blocks are uniformly spectrally stable. Under sufficient smoothness, we give a curvature criterion for second-order induced retractions and show that stable consistent polynomial acceleration preserves both the quadratic retraction expansion and this criterion. {As a special case, we establish new local R-linear convergence guarantees for fixed-degree Chebyshev-accelerated exact AP and second-order induced retractions. For uniform Friedrichs angle θ_Fin(0,π/2), acceleration strictly improves the local convergence rate per AP evaluation. The large-degree limiting spectral factor at fixed θ_F predicts O(θ_F^{-1}) evaluations for fixed relative error reduction as θ_Fdownarrow0, versus O(θ_F^{-2}) for ordinary AP.}} {The framework also covers} inexact, relaxed, and generalized AP {under their respective regularity and stability conditions.}

  • 2 authors
·
Oct 4

Certified Interface Aliases: Exact Collisions in Vision-Language Preprocessing, and When They Exist

Vision-language verifiers and routers must distinguish errors repairable by more reasoning from those caused by visual evidence never reaching the language model. This distinction lacks ground truth because annotators see full-resolution images while models receive preprocessed tensors. We introduce AliasForge to create cases where the relevant fact is provably absent from the interface. Fixed-point resampling makes the pre-rounding resize an exact integer linear map that can send nonzero integer perturbations to zero. Hiding a label-flipping perturbation there produces images with opposite step-correctness labels but bit-identical interface states. Every verifier therefore has the same output law on both members, giving pair-balanced accuracy exactly one half and zero gain from language-side repair. We prove that every fixed-point downscaler has such null vectors and bound their smallest size at the most common ratios, which rules out an 8-bit fit whenever the bound exceeds 255. From the resize configuration alone, a lattice criterion supplies realizable collisions and certifies their absence within the specified construction family. It resolves all 20 screened configurations, 17 as constructible and 3 as non-constructible. We construct certified pairs across three architectures and certify four additional processors, with zero decision-logit gap on all 18 scored pairs and none of the 18 controls. The pairs also screen routers that waste computation on re-attention or further reasoning. On natural items, per-item routing headroom exists, but no tested interface-only router improves over stopping. Our fiber ceiling bounds the headroom recoverable from the interface. Code: https://github.com/KurbanIntelligenceLab/aliasforge.

  • 4 authors
·
Sep 25

Convex-Hull-Neighborhood Smooth Dual Generalization: Controlling Local Correction Propagation in Offline RL

Offline reinforcement learning (offline RL) can benefit from nearby out-of-distribution (OOD) actions, but estimation errors at these actions may be amplified by bootstrapping. Existing regularization and local-generalization methods control either the admissible OOD region or the influence of generalized targets, often through separate mechanisms. We propose Convex Hull Neighborhood Smooth Dual Generalization (CSDG), which expresses the Bellman backup as an in-sample value target plus a CHN-local correction. This formulation makes the generalized contribution explicit and separates it from the in-sample reference path. The correction is obtained by smoothing in-sample-oriented and OOD-oriented candidates sampled at different perturbation radii. A mixture coefficient lambda scales its contribution to each backup, while the recursive discount remains gamma. Under boundedness and fixed perturbation kernels, we derive an exact one-step correction identity, a time-varying iterate bound, and a fixed-point bound that depends only on the branch discrepancy at the fixed point. We further characterize the implicit policies induced by the idealized operators and give a conditional non-degradation criterion. The practical algorithm approximates these quantities using asymmetric bounded noise and expectile regression, without exact support classification or an additional pessimistic OOD penalty. Experiments on Gym-MuJoCo and AntMaze show strong aggregate performance and stable value estimation. Code is available at: https://github.com/YOUNG-fnxm/CSDG

  • 6 authors
·
Aug 3

Trainable Fixed-Point Quantization for Deep Learning Acceleration on FPGAs

Quantization is a crucial technique for deploying deep learning models on resource-constrained devices, such as embedded FPGAs. Prior efforts mostly focus on quantizing matrix multiplications, leaving other layers like BatchNorm or shortcuts in floating-point form, even though fixed-point arithmetic is more efficient on FPGAs. A common practice is to fine-tune a pre-trained model to fixed-point for FPGA deployment, but potentially degrading accuracy. This work presents QFX, a novel trainable fixed-point quantization approach that automatically learns the binary-point position during model training. Additionally, we introduce a multiplier-free quantization strategy within QFX to minimize DSP usage. QFX is implemented as a PyTorch-based library that efficiently emulates fixed-point arithmetic, supported by FPGA HLS, in a differentiable manner during backpropagation. With minimal effort, models trained with QFX can readily be deployed through HLS, producing the same numerical results as their software counterparts. Our evaluation shows that compared to post-training quantization, QFX can quantize models trained with element-wise layers quantized to fewer bits and achieve higher accuracy on both CIFAR-10 and ImageNet datasets. We further demonstrate the efficacy of multiplier-free quantization using a state-of-the-art binarized neural network accelerator designed for an embedded FPGA (AMD Xilinx Ultra96 v2). We plan to release QFX in open-source format.

  • 7 authors
·
Jan 30, 2024

D2A: A Dataset Built for AI-Based Vulnerability Detection Methods Using Differential Analysis

Static analysis tools are widely used for vulnerability detection as they understand programs with complex behavior and millions of lines of code. Despite their popularity, static analysis tools are known to generate an excess of false positives. The recent ability of Machine Learning models to understand programming languages opens new possibilities when applied to static analysis. However, existing datasets to train models for vulnerability identification suffer from multiple limitations such as limited bug context, limited size, and synthetic and unrealistic source code. We propose D2A, a differential analysis based approach to label issues reported by static analysis tools. The D2A dataset is built by analyzing version pairs from multiple open source projects. From each project, we select bug fixing commits and we run static analysis on the versions before and after such commits. If some issues detected in a before-commit version disappear in the corresponding after-commit version, they are very likely to be real bugs that got fixed by the commit. We use D2A to generate a large labeled dataset to train models for vulnerability identification. We show that the dataset can be used to build a classifier to identify possible false alarms among the issues reported by static analysis, hence helping developers prioritize and investigate potential true positives first.

  • 9 authors
·
Feb 16, 2021

Large Landscape of 4d Superconformal Field Theories from Small Gauge Theories

We systematically explore the space of renormalization group flows of four-dimensional N=1 superconformal field theories (SCFTs) triggered by relevant deformations, as well as by coupling to free chiral multiplets with relevant operators. In this way, we classify all possible fixed point SCFTs that can be obtained from certain rank 1 and 2 supersymmetric gauge theories with small amount of matter multiplets, identifying 7,346 inequivalent fixed points which pass a series of non-trivial consistency checks. This set of fixed points exhibits interesting statistical behaviors, including a narrow distribution of central charges (a, c), a correlation between the number of relevant operators and the ratio a/c, and trends in the lightest operator dimension versus a/c. The ratio a/c of this set is distributed between 0.7228 and 1.2100, where the upper bound is larger than that of previously known interacting SCFTs. Moreover, we find a plethora of highly non-perturbative phenomena, such as (super)symmetry enhancements, operator decoupling, non-commuting renormalization group flows, and dualities. We especially identify amongst these fixed points a new SCFT that has smaller central charges (a, c) = (633{2000},683{2000}) than that of the deformed minimal Argyres-Douglas theory, as well as novel Lagrangian duals for certain N=1 deformed Argyres-Douglas theories. We provide a website https://qft.kaist.ac.kr/landscape to navigate through our set of fixed points.

  • 4 authors
·
Aug 21, 2024

Asymptotic Safety in Gauge Theories beyond Four Dimensions: Perturbative Tests and Fixed-Point Mergers

Non-Abelian gauge theories above four dimensions may admit an interacting ultraviolet fixed point through the competition between canonical scaling and gauge-field antiscreening. Using the four-loop mathrm{MS} beta function continued to D=4+2ε, we determine the largest dimension D_{pt}=4+2ε_{pt} below which successive loop corrections to the fixed point remain hierarchically ordered under a specified ratio criterion, and map D_{pt} over color and flavor numbers for fermions in the fundamental representation of SU(N). At D=5, we construct rational anomalous dimensions with a fixed, pole-regularized denominator inspired by the functional renormalization group (fRG). Matching to the mathrm{MS} series through one, two, and three loops produces progressively smaller shifts in the critical flavor number and coupling at the ultraviolet--infrared merger (the point where the infrared and ultraviolet fixed points coincide), yielding N_f^{cr}simeq 2.09 , N at large N in the three-loop construction. This low-order stabilization, together with qualitative evidence from fRG flows including higher gauge operators, suggests a potential merger scenario that bounds the candidate asymptotically safe region in flavor number. The resulting color--flavor map provides guidance for five-dimensional model building by displaying both the baseline perturbative-control boundary and the candidate three-loop merger boundary. Four-loop matching, however, retains an interacting ultraviolet fixed point beyond the three-loop merger boundary, with no merger found for integer 2le Nle15 and 0le N_f/Nle11/2. The sensitivity of the fixed-point structure to higher-order terms leaves both scenarios open, highlighting fixed-point annihilation as a potential constraint on five-dimensional asymptotic safety.

  • 5 authors
·
Oct 7

Self-Normalizing Neural Networks

Deep Learning has revolutionized vision via convolutional neural networks (CNNs) and natural language processing via recurrent neural networks (RNNs). However, success stories of Deep Learning with standard feed-forward neural networks (FNNs) are rare. FNNs that perform well are typically shallow and, therefore cannot exploit many levels of abstract representations. We introduce self-normalizing neural networks (SNNs) to enable high-level abstract representations. While batch normalization requires explicit normalization, neuron activations of SNNs automatically converge towards zero mean and unit variance. The activation function of SNNs are "scaled exponential linear units" (SELUs), which induce self-normalizing properties. Using the Banach fixed-point theorem, we prove that activations close to zero mean and unit variance that are propagated through many network layers will converge towards zero mean and unit variance -- even under the presence of noise and perturbations. This convergence property of SNNs allows to (1) train deep networks with many layers, (2) employ strong regularization, and (3) to make learning highly robust. Furthermore, for activations not close to unit variance, we prove an upper and lower bound on the variance, thus, vanishing and exploding gradients are impossible. We compared SNNs on (a) 121 tasks from the UCI machine learning repository, on (b) drug discovery benchmarks, and on (c) astronomy tasks with standard FNNs and other machine learning methods such as random forests and support vector machines. SNNs significantly outperformed all competing FNN methods at 121 UCI tasks, outperformed all competing methods at the Tox21 dataset, and set a new record at an astronomy data set. The winning SNN architectures are often very deep. Implementations are available at: github.com/bioinf-jku/SNNs.

  • 4 authors
·
Jun 8, 2017

Variance Reduced Halpern Iteration for Finite-Sum Monotone Inclusions

Machine learning approaches relying on such criteria as adversarial robustness or multi-agent settings have raised the need for solving game-theoretic equilibrium problems. Of particular relevance to these applications are methods targeting finite-sum structure, which generically arises in empirical variants of learning problems in these contexts. Further, methods with computable approximation errors are highly desirable, as they provide verifiable exit criteria. Motivated by these applications, we study finite-sum monotone inclusion problems, which model broad classes of equilibrium problems. Our main contributions are variants of the classical Halpern iteration that employ variance reduction to obtain improved complexity guarantees in which n component operators in the finite sum are ``on average'' either cocoercive or Lipschitz continuous and monotone, with parameter L. The resulting oracle complexity of our methods, which provide guarantees for the last iterate and for a (computable) operator norm residual, is mathcal{O}( n + nLvarepsilon^{-1}), which improves upon existing methods by a factor up to n. This constitutes the first variance reduction-type result for general finite-sum monotone inclusions and for more specific problems such as convex-concave optimization when operator norm residual is the optimality measure. We further argue that, up to poly-logarithmic factors, this complexity is unimprovable in the monotone Lipschitz setting; i.e., the provided result is near-optimal.

  • 3 authors
·
Oct 4, 2023

Low-Precision Training of Large Language Models: Methods, Challenges, and Opportunities

Large language models (LLMs) have achieved impressive performance across various domains. However, the substantial hardware resources required for their training present a significant barrier to efficiency and scalability. To mitigate this challenge, low-precision training techniques have been widely adopted, leading to notable advancements in training efficiency. Despite these gains, low-precision training involves several componentsx2013such as weights, activations, and gradientsx2013each of which can be represented in different numerical formats. The resulting diversity has created a fragmented landscape in low-precision training research, making it difficult for researchers to gain a unified overview of the field. This survey provides a comprehensive review of existing low-precision training methods. To systematically organize these approaches, we categorize them into three primary groups based on their underlying numerical formats, which is a key factor influencing hardware compatibility, computational efficiency, and ease of reference for readers. The categories are: (1) fixed-point and integer-based methods, (2) floating-point-based methods, and (3) customized format-based methods. Additionally, we discuss quantization-aware training approaches, which share key similarities with low-precision training during forward propagation. Finally, we highlight several promising research directions to advance this field. A collection of papers discussed in this survey is provided in https://github.com/Hao840/Awesome-Low-Precision-Training.

  • 9 authors
·
May 2, 2025 3

Input-Conditioned Search for Efficient Test-Time Scaling of Recursive Reasoners

People often tackle difficult problems by thinking more deeply or exploring more possibilities. Similarly, recursive reasoners, which reason by repeatedly applying a learned update rule to latent states, can also scale inference through more updates (depth) or additional trajectories generated by perturbing latent states (width). When people hit a dead end in their thinking, they may step back and approach the problem from a fresh angle. However, neither depth scaling nor perturbation-based width scaling of recursive reasoners can reliably achieve this: both may converge to incorrect attractors. To address this, we propose to explore diverse reasoning traces by applying different update maps to the same latent state, without any additional training. We realize this idea through Input-Conditioned Search (ICS), which searches over input conditions to induce alternative update maps from the pretrained reasoner. Across six reasoning tasks, ICS achieves the highest mean accuracy, while requiring up to two orders of magnitude fewer model FLOPs than the evaluated scaling baselines. Controlled experiments confirm that ICS can redirect trajectories from the same state. Our theoretical analysis and rigorous numerical verification also confirm that ICS can locally eliminate incorrect attracting fixed points. Together, these findings establish ICS as an effective axis for efficient test-time scaling and motivate further research on shaping recursive reasoning during training and at test time.

  • 10 authors
·
Oct 12

A Unified Debugging Approach via LLM-Based Multi-Agent Synergy

Tremendous efforts have been devoted to automating software debugging, a time-consuming process involving fault localization and repair generation. Recently, Large Language Models (LLMs) have shown great potential in automated debugging. However, we identified three challenges posed to traditional and LLM-based debugging tools: 1) the upstream imperfection of fault localization affects the downstream repair, 2) the deficiency in handling complex logic errors, and 3) the ignorance of program contexts. In this context, we propose the first automated, unified debugging framework, FixAgent, via LLM agent synergy. FixAgent can perform end-to-end localization, repair, and analysis of bugs. Our insight is that LLMs can benefit from general software engineering principles recognized by human developers in debugging, such as rubber duck debugging, enabling a better understanding of program functionality and logic bugs. Hence, we create three designs inspired by rubber ducking to address these challenges. They are agent specialization and synergy, key variable tracking, and program context comprehension, which request LLMs to provide explicit explanations and force them to focus on crucial program logic information. Experiments on the widely used dataset QuixBugs show that FixAgent correctly fixes 79 out of 80 bugs, 9 of which have never been fixed. It also plausibly patches 1.9X more defects than the best-performing repair tool on CodeFlaws, even with no bug location information and fewer than 0.6% sampling times. On average, FixAgent increases about 20% plausible and correct fixes compared to its base model using different LLMs, showing the effectiveness of our designs. Moreover, the correctness rate of FixAgent reaches remarkably 97.26%, indicating that FixAgent can potentially overcome the overfitting issue of the existing approaches.

  • 6 authors
·
Apr 26, 2024

FormaTheoria: Constructing Large-Scale Lean Theories from Mathematical Literature - Toward the Formalization of the Classification of Finite Simple Groups

Large-scale formalization of advanced mathematics requires more than translating individual statements: it must reconstruct a coherent theory distributed across heterogeneous sources. This process raises four challenges: discovering implicit dependencies, correcting source defects, preserving semantic fidelity, and reconciling cross-source misalignments. We present FormaTheoria, an end-to-end, AI-assisted workflow that coordinates source acquisition, formalization, proof construction, recursive dependency discovery, independent review, and reconciliation, while preserving provenance and protecting approved declarations. A shared agent framework supports long-horizon execution through tool use, context compaction, review-gated termination, section-level source context, and dependency-aware batch parallelization. Applying FormaTheoria to major components of the Classification of Finite Simple Groups (CFSG), we construct a machine-checked Lean development extending through the Bender--Suzuki theorem and encompassing the Feit--Thompson Odd Order Theorem, Glauberman's Z^* theorem, and the Brauer--Suzuki theorem. This development verifies an extensive body of deeply interdependent finite-group theory while providing a foundation for continuing the CFSG formalization. An empirical analysis of the code and recorded construction process supports the practical relevance of the identified challenges and illustrates the roles of the corresponding workflow components. Together, these results demonstrate how AI-assisted workflows can reconstruct mathematically significant formal theories from distributed literature by combining language-model agents with formal verification, structured review, and explicit dependency management.

  • 7 authors
·
Aug 10

More with Less: An Empirical Study of Turn-Control Strategies for Efficient Coding Agents

LLM-powered coding agents, which operate in iterative loops (turns) to solve software engineering tasks, are becoming increasingly powerful. However, their practical deployment is hindered by significant and unpredictable costs. This challenge arises from a combination of factors: quadratically growing token counts with each turn, the high price of models, the large number of turns required for real-world tasks, and the tendency of agents to take inefficient or unnecessary actions. While existing research focuses on optimizing individual turns, the strategic control of the total number of turns remains an underexplored area for managing agent performance and cost. To address this gap, we conduct a comprehensive empirical study on SWE-bench using three state-of-the-art models and evaluate the impact of three distinct turn-control strategies: an unrestricted baseline, a fixed-turn limit with reminders, and a novel dynamic-turn strategy that grants extensions on-demand. Our findings first reveal a fundamental trade-off in the unrestricted setting, where no single model excels across performance, cost, and turn efficiency. We then show that a fixed-turn limit, specifically at the 75th percentile of the baseline, serves as a "sweet spot", substantially reducing costs (by 24%-68%) with minimal impact on solve rates. Most significantly, the dynamic-turn strategy consistently outperforms fixed-limit approaches, achieving comparable or better solve rates while further reducing costs by an additional 12%-24% by intelligently allocating resources only to tasks that need them. This work provides the first systematic analysis of turn-control strategies, offering simple yet effective guidelines for developers to balance cost and efficacy. We demonstrate that dynamic resource allocation is a superior, easy-to-implement approach for deploying powerful yet economically viable coding agents.

  • 2 authors
·
Oct 19, 2025

Compound Estimation for Binomials

Many applications involve estimating the mean of multiple binomial outcomes as a common problem -- assessing intergenerational mobility of census tracts, estimating prevalence of infectious diseases across countries, and measuring click-through rates for different demographic groups. The most standard approach is to report the plain average of each outcome. Despite simplicity, the estimates are noisy when the sample sizes or mean parameters are small. In contrast, the Empirical Bayes (EB) methods are able to boost the average accuracy by borrowing information across tasks. Nevertheless, the EB methods require a Bayesian model where the parameters are sampled from a prior distribution which, unlike the commonly-studied Gaussian case, is unidentified due to discreteness of binomial measurements. Even if the prior distribution is known, the computation is difficult when the sample sizes are heterogeneous as there is no simple joint conjugate prior for the sample size and mean parameter. In this paper, we consider the compound decision framework which treats the sample size and mean parameters as fixed quantities. We develop an approximate Stein's Unbiased Risk Estimator (SURE) for the average mean squared error given any class of estimators. For a class of machine learning-assisted linear shrinkage estimators, we establish asymptotic optimality, regret bounds, and valid inference. Unlike existing work, we work with the binomials directly without resorting to Gaussian approximations. This allows us to work with small sample sizes and/or mean parameters in both one-sample and two-sample settings. We demonstrate our approach using three datasets on firm discrimination, education outcomes, and innovation rates.

  • 2 authors
·
Dec 30, 2025

Chinese vs. World Bank Development Projects: Insights from Earth Observation and Computer Vision on Wealth Gains in Africa, 2002-2013

Debates about whether development projects improve living conditions persist, partly because observational estimates can be biased by incomplete adjustment and because reliable outcome data are scarce at the neighborhood level. We address both issues in a continent-scale, sector-specific evaluation of Chinese and World Bank projects across 9,899 neighborhoods in 36 African countries (2002 to 2013), representative of 88% of the population. First, we use a recent dataset that measures living conditions with a machine-learned wealth index derived from contemporaneous satellite imagery, yielding a consistent panel of 6.7 km square mosaics. Second, to strengthen identification, we proxy officials' map-based placement criteria using pre-treatment daytime satellite images and fuse these with rich tabular covariates to estimate funder- and sector-specific ATEs via inverse-probability weighting. Incorporating imagery systematically shrinks effects relative to tabular-only models, indicating prior work likely overstated benefits. On average, both donors raise wealth, with larger gains for China; sector extremes in our sample include Trade and Tourism for the World Bank (+6.27 IWI points), and Emergency Response for China (+14.32). Assignment-mechanism analyses show World Bank placement is generally more predictable from imagery alone, as well as from tabular covariates. This suggests that Chinese project placements are more driven by non-visible, political, or event-driven factors than World Bank placements. To probe residual concerns about selection on observables, we also estimate within-neighborhood (unit) fixed-effects models at a spatial resolution about 450 times finer than prior fixed effects analyses, leveraging the computer-vision-imputed IWI panels; these deliver smaller but directionally consistent effects.

Dynamic Constrained Submodular Optimization with Polylogarithmic Update Time

Maximizing a monotone submodular function under cardinality constraint k is a core problem in machine learning and database with many basic applications, including video and data summarization, recommendation systems, feature extraction, exemplar clustering, and coverage problems. We study this classic problem in the fully dynamic model where a stream of insertions and deletions of elements of an underlying ground set is given and the goal is to maintain an approximate solution using a fast update time. A recent paper at NeurIPS'20 by Lattanzi, Mitrovic, Norouzi{-}Fard, Tarnawski, Zadimoghaddam claims to obtain a dynamic algorithm for this problem with a 1{2} -epsilon approximation ratio and a query complexity bounded by poly(log(n),log(k),epsilon^{-1}). However, as we explain in this paper, the analysis has some important gaps. Having a dynamic algorithm for the problem with polylogarithmic update time is even more important in light of a recent result by Chen and Peng at STOC'22 who show a matching lower bound for the problem -- any randomized algorithm with a 1{2}+epsilon approximation ratio must have an amortized query complexity that is polynomial in n. In this paper, we develop a simpler algorithm for the problem that maintains a (1{2}-epsilon)-approximate solution for submodular maximization under cardinality constraint k using a polylogarithmic amortized update time.

  • 6 authors
·
May 24, 2023

Counterfactual Generation via Flow Matching: Coupling-Sensitive End-to-End Rates

Counterfactual generation seeks to sample outcomes under a hypothetical intervention or decision using observational data collected under the factual assignment mechanism. We develop a flow-matching approach that combines a sample-split, doubly robust training objective with a learned coupling between observed source outcomes and target outcomes drawn from a fitted conditional outcome model. To enable finite-step generation, we leverage a score-corrected stochastic sampler based on a Gaussian-smoothed interpolation. Our main theoretical contribution is a coupling-sensitive KL bound for constant-step Euler discretization: the error is controlled by moments of the source--target displacement under the chosen coupling, rather than by global uniform regularity of the velocity field, and has near-linear dependence on the ambient dimension. We also establish finite-sample non-parametric guarantees for the learned velocity and score fields when both the conditional outcome model and the source-target coupling are estimated from data. These bounds separate approximation, coupling-replacement, nuisance-estimation, generalization, and Monte Carlo errors and, combined with the sampler analysis, yield an end-to-end guarantee for counterfactual generation. Experiments on synthetic and semi-synthetic image benchmarks support the coupling-dependent theory and show that, at finite discretization budgets, the stochastic sampler can outperform the corresponding deterministic ODE sampler.

  • 3 authors
·
Sep 30

Re^2Math: Benchmarking Theorem Retrieval in Research-Level Mathematics

Large language models are increasingly capable at closed-world mathematical reasoning, but research assistance also requires source-grounded use of the literature. When a proof reaches a non-trivial step, a useful assistant should determine whether the needed tool (e.g., a lemma) already exists, identify a suitable scholarly source, and verify that its assumptions align with the current proof context. To rigorously evaluate such capabilities, we introduce Re^2Math, a benchmark for tool-grounded retrieval from partial mathematical proofs. Each instance is built from a candidate instrumental citation in the proof of a main theorem, with hierarchical context and an optional leakage-controlled anchor hint. We also make the task source-grounded yet citation-agnostic in that any admissible theorem sufficient for the proof transition is accepted. Evaluation uses a release-frozen retrieval artifact, ensuring reproducibility, while the benchmark itself supports automatic, continual expansion with newly constructed instances. On the current benchmark test set, the best fixed-judge ToolAcc reaches 7.0%, despite substantially higher rates of source grounding, indicating that current systems often retrieve valid statements but fail to establish their applicability to the local proof step. By decoupling citation recall, grounding, and proof-gap sufficiency, Re^2Math transforms literature-grounded mathematical tool use into a controlled diagnostic task.

  • 4 authors
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May 8

Lyra: Orchestrating Dual Correction in Automated Theorem Proving

Large Language Models (LLMs) present an intriguing avenue for exploration in the field of formal theorem proving. Nevertheless, their full potential, particularly concerning the mitigation of hallucinations and refinement through prover error messages, remains an area that has yet to be thoroughly investigated. To enhance the effectiveness of LLMs in the field, we introduce the Lyra, a new framework that employs two distinct correction mechanisms: Tool Correction (TC) and Conjecture Correction (CC). To implement Tool Correction in the post-processing of formal proofs, we leverage prior knowledge to utilize predefined prover tools (e.g., Sledgehammer) for guiding the replacement of incorrect tools. Tool Correction significantly contributes to mitigating hallucinations, thereby improving the overall accuracy of the proof. In addition, we introduce Conjecture Correction, an error feedback mechanism designed to interact with prover to refine formal proof conjectures with prover error messages. Compared to the previous refinement framework, the proposed Conjecture Correction refines generation with instruction but does not collect paired (generation, error & refinement) prompts. Our method has achieved state-of-the-art (SOTA) performance on both miniF2F validation (48.0% -> 55.3%) and test (45.5% -> 51.2%). We also present 3 IMO problems solved by Lyra. We believe Tool Correction (post-process for hallucination mitigation) and Conjecture Correction (subgoal adjustment from interaction with environment) could provide a promising avenue for future research in this field.

  • 9 authors
·
Sep 27, 2023

A Taxonomy of Event-Linked Perpetual Futures: Variant Designs Beyond the Single-Market Binary Case

Paper 1 of this research programme develops a resolution-aware risk-design framework for the simplest event-linked perpetual: a contract whose underlying tracks a single binary prediction-market probability through resolution. The instrument class is broader. Variants span conditional probabilities P(A|B), spreads p^A - p^B, weighted baskets sum w_i p^(i), derivatives on variance or entropy of the probability process, contracts on liquidity itself, perpetual-on-expiring-event roll structures, and funding-only derivatives with no settlement. Each variant inherits some framework components from the single-market binary case and requires its own design adaptations. This paper develops a formal taxonomy of seven pure-form canonical variants beyond the probability-index perpetual of Paper 1, organised along four orthogonal design axes: underlying geometry, temporal structure, settlement structure, and venue composition. The list is not exhaustive; combinations are not treated separately. For each variant we provide a precise payoff definition; an inheritance map identifying which Paper 1 components carry over, are modified, or fail; variant-specific design constraints; microstructure properties; empirical evaluability on the PMXT v2 archive; and limitations. Notable findings: the conditional variant admits a candidate non-portability proposition (denominator instability as the conditioning event becomes improbable); the spread variant requires a three-channel decomposition of resolution risk; the volatility/entropy variant avoids random binary terminal-collapse but introduces estimator-convention and entropy-decay issues; the basket variant requires multi-period jump-aware margin whose aggregation is correlation-dependent. The paper is theoretical primarily; it specifies how demonstrative time series can be constructed and provides evaluability criteria to guide future work.

  • 1 authors
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May 10

Hierarchical Melnikov Realization: Logarithmic Factor Improvement to Hilbert Number Lower Bounds

The second part of Hilbert's 16th problem is one of the most fundamental open problems in the qualitative theory of ordinary differential equations and dynamical systems. A central unresolved question is whether the Hilbert number H(d) is finite for arbitrary polynomial degree d. (A very recent manuscript from OpenAI asserts the finiteness of H(d); see the remark at the end of this paper.) In the absence of a general upper bound theory, most existing work constructs explicit perturbed polynomial systems to obtain improved lower bounds for H(d), while rigorous upper bound estimates remain largely unavailable. This paper focuses on improving the quantitative lower bound for polynomial systems through a systematic Hierarchical Melnikov Realization framework. We construct perturbed dynamics based on an anisotropic Chebyshev Hamiltonian, where hierarchically selected perturbation coefficients generate simple zeros of the first-order Melnikov function simultaneously across multiple disjoint period annuli. Two distinct 3-adic filtrations supply the necessary logarithmic correction factors, and a Borel--Gauss analysis establishes the required local rank condition under sufficiently strong anisotropy. As the main result of this work, we prove that H(d)=Ωbigl(d^2ln^2 dbigr), which improves the previously known lower bound by a factor of ln d. The full construction of limit cycles and the resulting dynamical bounds are formally certified using Lean 4 formal verification.

  • 2 authors
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Oct 7

EasyTPP: Towards Open Benchmarking Temporal Point Processes

Continuous-time event sequences play a vital role in real-world domains such as healthcare, finance, online shopping, social networks, and so on. To model such data, temporal point processes (TPPs) have emerged as the most natural and competitive models, making a significant impact in both academic and application communities. Despite the emergence of many powerful models in recent years, there hasn't been a central benchmark for these models and future research endeavors. This lack of standardization impedes researchers and practitioners from comparing methods and reproducing results, potentially slowing down progress in this field. In this paper, we present EasyTPP, the first central repository of research assets (e.g., data, models, evaluation programs, documentations) in the area of event sequence modeling. Our EasyTPP makes several unique contributions to this area: a unified interface of using existing datasets and adding new datasets; a wide range of evaluation programs that are easy to use and extend as well as facilitate reproducible research; implementations of popular neural TPPs, together with a rich library of modules by composing which one could quickly build complex models. All the data and implementation can be found at https://github.com/ant-research/EasyTemporalPointProcess. We will actively maintain this benchmark and welcome contributions from other researchers and practitioners. Our benchmark will help promote reproducible research in this field, thus accelerating research progress as well as making more significant real-world impacts.

  • 12 authors
·
Jul 16, 2023

Unravelling the Probabilistic Forest: Arbitrage in Prediction Markets

Polymarket is a prediction market platform where users can speculate on future events by trading shares tied to specific outcomes, known as conditions. Each market is associated with a set of one or more such conditions. To ensure proper market resolution, the condition set must be exhaustive -- collectively accounting for all possible outcomes -- and mutually exclusive -- only one condition may resolve as true. Thus, the collective prices of all related outcomes should be \1, representing a combined probability of 1 of any outcome. Despite this design, Polymarket exhibits cases where dependent assets are mispriced, allowing for purchasing (or selling) a certain outcome for less than (or more than) 1, guaranteeing profit. This phenomenon, known as arbitrage, could enable sophisticated participants to exploit such inconsistencies. In this paper, we conduct an empirical arbitrage analysis on Polymarket data to answer three key questions: (Q1) What conditions give rise to arbitrage (Q2) Does arbitrage actually occur on Polymarket and (Q3) Has anyone exploited these opportunities. A major challenge in analyzing arbitrage between related markets lies in the scalability of comparisons across a large number of markets and conditions, with a naive analysis requiring O(2^{n+m}) comparisons. To overcome this, we employ a heuristic-driven reduction strategy based on timeliness, topical similarity, and combinatorial relationships, further validated by expert input. Our study reveals two distinct forms of arbitrage on Polymarket: Market Rebalancing Arbitrage, which occurs within a single market or condition, and Combinatorial Arbitrage, which spans across multiple markets. We use on-chain historical order book data to analyze when these types of arbitrage opportunities have existed, and when they have been executed by users. We find a realized estimate of 40 million USD of profit extracted.

  • 4 authors
·
Aug 4, 2025

Bounded Reachability & Jailbreak Detection via Contraction-Constrained State Space Models

Safety heads are lightweight classifiers attached to pretrained language models for flagging harmful inputs before generation. Their empirical detection performance has been studied, but their formal robustness properties remain largely unexplored. We ask when a State Space Model (SSM)-based safety head can be certified to produce the same prediction for all inputs within a bounded embedding-space perturbation. We prove that the answer turns on a single condition: the l_infty norm of the state transition matrix must satisfy A_infty<1 (the contraction condition), which enables exact interval bound propagation (IBP) certification for linear time-invariant classifiers. When the contraction condition holds, the reachable output interval has bounded steady-state width and examples can be certified as robustly classified. When it fails, the interval grows exponentially with sequence length and certification is impossible at any practical perturbation radius. We enforce contraction with a hinge penalty and show on toxic comment data that certified fraction improves from 41\% to 59\%, with a sharp empirical phase transition at A_infty=1 matching the theory. Applying a contraction-regularized S4 head to jailbreak detection on JailbreakBench, we achieve a zero-shot transfer to AdvBench (DR=0.994) and HarmBench (DR=0.988). A logistic regression on mean-pooled Mamba-130M embeddings matches or exceeds the S4 head on every detection metric, confirming that harmful intent is already linearly separable in the embedding space. The S4 safety head's contribution is not superior discrimination but the formal certification that no probe-based approach provides.

  • 1 authors
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Oct 1

Tail-Influence Sampling for CVaR Policy Evaluation

Policies with similar mean returns can differ sharply in rare failures, yet estimating lower-tail conditional value-at-risk (CVaR) accurately can require many costly rollouts. When different conditional components of a stochastic workflow can be queried separately, we ask how to allocate a fixed evaluation budget to estimate a fixed policy's CVaR most accurately. We derive a tail influence for each queryable conditional law that aggregates how its uncertainty affects CVaR across every Bellman reuse. Its variance yields the fixed-design efficiency bound and the oracle Neyman allocation. Tail-Influence Sampling (TIS) estimates these influence scales from a pilot model and reallocates fresh queries toward kernels that matter most for the tail; a visitation-anchored variant protects against pilot underallocation. Under fixed dimension and a positive quantile margin, TIS attains oracle asymptotic variance and first-order MSE including pilot cost, while the anchored variant is within a factor two of the oracle. We also characterize an exact-grid regime in which tail- and mean-optimal allocations coincide. On CliffWalking, TIS reduces MSE by 41% versus learned occupancy and 76% versus complete rollouts at the same charged transition budget. In frozen language-model review workflows, anchored TIS beats an equally regularized mean-influence blend in 23 of 24 MMLU-Pro settings and reaches 2.4-3.4times lower MSE than rollouts on six-call FinQA reviews.

LLM Swiss Round: Aggregating Multi-Benchmark Performance via Competitive Swiss-System Dynamics

The rapid proliferation of Large Language Models (LLMs) and diverse specialized benchmarks necessitates a shift from fragmented, task-specific metrics to a holistic, competitive ranking system that effectively aggregates performance across multiple ability dimensions. Primarily using static scoring, current evaluation methods are fundamentally limited. They struggle to determine the proper mix ratio across diverse benchmarks, and critically, they fail to capture a model's dynamic competitive fitness or its vulnerability when confronted with sequential, high-stakes tasks. To address this, we introduce the novel Competitive Swiss-System Dynamics (CSD) framework. CSD simulates a multi-round, sequential contest where models are dynamically paired across a curated sequence of benchmarks based on their accumulated win-loss record. And Monte Carlo Simulation (N=100,000 iterations) is used to approximate the statistically robust Expected Win Score (E[S_m]), which eliminates the noise of random pairing and early-round luck. Furthermore, we implement a Failure Sensitivity Analysis by parameterizing the per-round elimination quantity (T_k), which allows us to profile models based on their risk appetite--distinguishing between robust generalists and aggressive specialists. We demonstrate that CSD provides a more nuanced and context-aware ranking than traditional aggregate scoring and static pairwise models, representing a vital step towards risk-informed, next-generation LLM evaluation.

ByteDance-Seed ByteDance Seed
·
Dec 24, 2025 2

Cost-effectiveness analysis for therapy sequence in advanced cancer: A microsimulation approach with application to metastatic prostate cancer

Purpose. Patients with advanced cancer may undergo multiple lines of treatment, switching therapies as their disease progresses. Motivated by a study of metastatic prostate cancer, we develop a microsimulation framework to study therapy sequence. Methods. We propose a discrete-time state transition model to study two lines of anti-cancer therapy. Based on digitized published progression-free survival (PFS) and overall survival (OS) curves, we infer event types (progression or death), and estimate transition probabilities using cumulative incidence functions with competing risks. Our model incorporates within-patient dependence over time, such that response to first-line therapy informs subsequent event probabilities. Parameters governing the degree of within-patient dependence can be used to calibrate the model-based results to those of a target trial. We demonstrate these methods in a study of two therapy sequences for metastatic prostate cancer, where Docetaxel (DCT) and Abiraterone Acetate (AA) are both appropriate for use in either first or second line treatment. We assess costs, Quality-Adjusted Life Years (QALYs) and Incremental Cost Effectiveness Ratio (ICER) for two treatment strategies: DCT then AA vs AA then DCT. Results. Using digitized survival curves from relevant clinical trials, we identified 8.6-13.9% of PFS times that should be categorized as deaths, allowing for estimation of cumulative incidence functions. Models assuming within-patient independence overestimated OS time, corrected with our calibration approach. Correction resulted in meaningful changes in the difference in QALYs between treatment strategies (0.07 vs 0.15) and the ICER (-\76,836/QALY vs -21,030/QALY). Conclusions. Microsimulation models can be successfully used to study cost-effectiveness of therapy sequences, taking care to account correctly for within-patient dependence.

  • 5 authors
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Oct 10, 2022